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“I always have a game plan. VYNDAMAX is part of my game plan.”
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— Jack Nicklaus, VYNDAMAX patient
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VYNDAMAX helps people with transthyretin cardiac amyloidosis (ATTR-CM) live longer compared to placebo
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- VYNDAMAX* was studied in the “Tafamidis in Transthyretin Amyloidosis Cardiomyopathy Clinical Trial” (known as ATTR-ACT)
- The study tested if VYNDAMAX could help people with ATTR-CM live longer and reduce hospitalizations due to heart problems compared to placebo
- The study also tested the impact of VYNDAMAX on quality of life and ability to function
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*The clinical studies of VYNDAQEL® (a different form of tafamidis) supported the approval of VYNDAMAX. Both drugs contain the same active ingredient.
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How was VYNDAMAX studied?
The safety and efficacy of VYNDAMAX were studied in a 30-month clinical study of 441 adult patients with wild-type or hereditary ATTR-CM.
- The VYNDAMAX study primarily focused on the reduction of death and heart-related hospitalizations, as well as safety
- VYNDAMAX was also assessed on other aspects of ATTR-CM, including walking distance (6-Minute Walk Test) and health-related quality of life
- Efficacy and safety were determined by comparing patients treated with VYNDAMAX (n=264), with patients who did not take VYNDAMAX (placebo) (n=177)
- Patients were evaluated every 6 months for a total of 30 months
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VYNDAMAX was proven to help people live longer
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After 2 1/2 YEARS more people were alive taking VYNDAMAX than placebo
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VYNDAMAX was proven to reduce hospitalizations for heart problems
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In the study, patients taking VYNDAMAX had fewer heart-related hospitalizations than those in the placebo group
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Health-related quality-of-life measures†
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In a 2.5-year clinical study, compared to those not on treatment (placebo group), people taking VYNDAMAX reported:
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†At the end of the 30-month study compared to people taking a placebo. The Kansas City Cardiomyopathy Questionnaire (KCCQ) was used to measure health-related quality of life. Patients in the VYNDAMAX and placebo groups had worse KCCQ overall summary scores at month 30 than at the start of the study.
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Better quality of life
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(mental health status, enjoyment of life)
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Fewer heart-related symptoms
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(shortness of breath, fatigue, swollen feet or ankles)
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More comfort performing daily activities
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(ability to perform social and physical activities)
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While there's no cure today, VYNDAMAX slows down ATTR-CM
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Remember that even if you don’t feel it working, always take VYNDAMAX as prescribed. It’s important to tell your doctor how you are feeling.
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Heart function and exercise capacity were measured in patients taking VYNDAMAX
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The 6-Minute Walk Test (6MWT) measured heart function and exercise capacity.
At 30 months, people who took VYNDAMAX were able to walk a significant 83 yards farther (almost the length of a football field) on average than people who did not take VYNDAMAX (placebo).‡
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‡Patients in the VYNDAMAX and placebo groups had worse 6-minute walking distance than at the start of the study.
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Create a discussion guide to help you log your symptoms and talk to your doctor about ATTR-CM
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“I want to be here for the legacy that matters most: my family.”
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— Jack Nicklaus, VYNDAMAX patient
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Cardiologist Recommended
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VYNDAMAX is a treatment with a Class 1§ recommendation for ATTR-CM in guidelines from:
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- American College of Cardiology
- American Heart Association
- Heart Failure Society of America
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§Class 1 guidelines are given when there’s strong evidence or general agreement that a treatment is beneficial, useful, and effective. The above recommendation is from the 2022 guidelines.
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Get to the heart of what matters
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Stay informed with educational materials about ATTR-CM and VYNDAMAX.
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Hear from other real patients
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