ATTR-CM, or transthyretin cardiac amyloidosis, is a heart condition that often goes unnoticed and gets worse over time
- ATTR-CM happens when a protein called transthyretin (TTR) breaks down and turns into amyloid. Amyloid can build up in the heart making it harder for the heart to pump effectively
- The amyloid can also build up in other parts of the body. This results in worsening symptoms and problems like:
- carpal tunnel syndrome
- lumbar spinal stenosis
- stomach issues
- peripheral neuropathy
Your liver produces transthyretin (TTR). TTR is a protein that carries a hormone and vitamin A throughout the bloodstream.
When you have transthyretin amyloid cardiomyopathy (ATTR-CM), the TTR protein becomes unstable and misfolds.
Over time, the misfolded proteins build up in the heart. This can cause the muscles in the heart to get thick and stiff, which can lead to heart failure.
It’s important to work with your cardiologist to rule out ATTR-CM.
Create a discussion guide to help you log your symptoms and talk to your doctor about ATTR-CM
ATTR-CM has 2 subtypes:

Wild-type ATTR-CM (wtATTR)
- Wild-type ATTR-CM (wtATTR) occurs when the transthyretin (TTR) protein becomes unstable with age and misfolds
- It mainly affects White men over 60 years old

Hereditary ATTR-CM (hATTR)
- Hereditary ATTR-CM (hATTR) is caused by a change, or mutation, in the TTR gene passed down from a relative
- The most common mutations associated with hATTR in the US are V122I (found almost exclusively in Black Americans) and T60A (found in those of Irish descent)
- Symptoms of hATTR can occur as early as age 50-60
Hear from Stan, a real patient taking VYNDAMAX
“Once I learned that VYNDAMAX can help to slow the progression of ATTR-CM, I was eager to begin the treatment journey."
If you think you may be at risk for ATTR-CM, don’t wait. An early diagnosis is key to helping you live longer.
Tips if you’re newly diagnosed with ATTR-CM:
- Understand that ATTR-CM is a rare, life-threatening, progressive heart condition, which means it will get worse over time
- Discuss treatment options with your doctor as soon as your diagnosis is confirmed. The sooner you start treatment, the sooner you can begin to slow disease progression
- It can be helpful to connect with other people diagnosed with ATTR-CM
If you’ve been diagnosed with hereditary ATTR-CM, your loved ones may also be at risk.
It’s important for patients with hereditary ATTR-CM to tell their families about their condition. This allows family members to make a decision as to whether they want to pursue genetic testing and counseling.
Genetic testing will help confirm or rule out the hereditary form of ATTR-CM and may help identify family members who are at risk. Genetic testing is typically performed using blood or saliva samples.
Genetic counseling may be available to help those diagnosed with hereditary ATTR-CM (and their families) to understand test results and potential next steps.