Transthyretin amyloid cardiomyopathy (ATTR-CM) is a form of amyloidosis

Amyloidosis (pronounced am-uh-loi-DO-sis)

is a group of diseases in which certain abnormal proteins can build up over time and affect different parts of the body.

ATTR-CM, which stands for transthyretin (pronounced trans-THY-re-tin) amyloid cardiomyopathy,

is a serious and underdiagnosed type of amyloidosis that primarily affects the heart and leads to heart failure.




It’s important to understand that ATTR-CM is a progressive condition (meaning it will get worse over time). Learn more about how VYNDAMAX works.




Subtypes of ATTR-CM

The 2 subtypes of ATTR-CM are wild type and hereditary.

Wild-type ATTR-CM (wtATTR)

Wild-type ATTR-CM is associated with aging. It occurs when the transthyretin (TTR) protein becomes unstable with age and misfolds. It mainly affects white/Caucasian men over 60 years old.

Hereditary ATTR-CM (hATTR)

hATTR is caused by a change, or mutation, in the TTR gene that is passed down from a relative.

  • There are more than 120 known mutations that cause hATTR
  • The most common mutation associated with hATTR in the US, known as V122I, is found almost exclusively in African Americans. Approximately 3% to 4% of African Americans in the US are thought to have the V122I mutation. Not all individuals with the V122I mutation develop symptoms of hereditary ATTR-CM
  • Symptoms of hATTR can occur as early as age 50 or 60