Vyndamax ( Tafamidis )

ABOUT ATTR-CM

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COULD THESE SYMPTOMS ACTUALLY BE ATTR-CM?

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HEART FAILURE
SYMPTOMS
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A HISTORY OF CARPAL
TUNNEL SYNDROME
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PAIN OR NUMBNESS
IN LOWER BACK
OR LEGS

If you’re over 60 years old with heart failure symptoms, carpal tunnel syndrome and/or lumbar spinal stenosis, and your heart and blood pressure medicines only make you feel worse, you could have a life-threatening disease. Scroll down for more about transthyretin-mediated amyloidosis, or ATTR-CM.

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IF YOU HAVE HEART FAILURE, TELL YOUR DOCTOR
IF YOU HAVE HAD ANY OR ALL OF THESE SYMPTOMS.
IT COULD BE ATTR-CM.

  • Heart failure
  • Feeling worse when taking heart medications such as beta blockers, ACE inhibitors, or ARBs
  • Echocardiography showing increased left ventricle wall thickness
  • An electrocardiogram reading of low electrical activity relative to left ventricle thickness
  • Arrhythmia, also known as an irregular heartbeat
  • Narrowing of the aortic valve ("aortic stenosis")
  • Nerve damage that can affect the heart, blood vessels, bladder, intestines, sweat glands, and pupils (“autonomic neuropathy”)
  • Stomach or digestive problems like diarrhea, constipation, and nausea
  • Unexplained weight loss
  • Dizziness or lightheadedness when standing up
  • Sexual impotence
  • Nerve damage that can affect muscle movement and sensation, and/or cause tingling, numbness, and pain in the arms and legs
  • The appearance of tiny threads or “floaters” in one’s field of vision (“vitreous opacity”)
  • Glaucoma, a buildup of fluid in the eye that can lead to blindness
  • Biceps tendon rupture
  • Pain and numbness in the lower back and legs due to a narrowing of the lower spinal canal (“lumbar stenosis”)
  • A history of carpal tunnel syndrome
  • Surgery to resurface or replace parts of the hip or knee joint (“arthroplasty”)
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WHAT DOES
MY DOCTOR
DO NEXT?

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Your doctor may perform some tests to get more detailed information about your heart, including an electrocardiogram, an echocardiogram, or a cardiac MRI.

If those tests suggest that ATTR-CM might be causing your symptoms, your doctor may order blood and urine tests to rule out other diseases. 

Next steps can include procedures that might definitively diagnose ATTR-CM, like a cardiac imaging scan. 
This noninvasive procedure can help show if transthyretin deposits are forming in your heart, an indication that you have ATTR-CM. In some cases, your doctor will order a heart biopsy to look for transthyretin deposits.

If you are diagnosed with ATTR-CM,
there's a treatment that can help.

IMPORTANT SAFETY INFORMATION AND INDICATION

Before taking VYNDAMAX, tell your healthcare provider about all your medical conditions, including if you:
  • have liver problems.
  • are pregnant or plan to become pregnant.
  • are breastfeeding or plan to breastfeed.
Tell your healthcare provider about all the medicines you take including any prescription or over‑the‑counter medicines, vitamins, and herbal supplements.
There were no known side effects that happened during treatment with VYNDAMAX.
What is VYNDAMAX?
VYNDAMAX is a prescription medicine used to treat adults with the cardiomyopathy of wild-type or hereditary transthyretin-mediated amyloidosis (ATTR-CM) to reduce death and hospitalization related to heart problems. It is not known if VYNDAMAX is safe and effective in children.
Tell your healthcare provider about all the medicines you take including any prescription or over‑the‑counter medicines, vitamins, and herbal supplements.
There were no known side effects that happened during treatment with VYNDAMAX.
What is VYNDAMAX?
VYNDAMAX is a prescription medicine used to treat adults with the cardiomyopathy of wild-type or hereditary transthyretin-mediated amyloidosis (ATTR-CM) to reduce death and hospitalization related to heart problems. It is not known if VYNDAMAX is safe and effective in children.