ATTR-CM affects the heart and can also affect many other parts of the body

For people who have been diagnosed with heart failure and are experiencing unresolved symptoms, ATTR-CM may be the cause.

How ATTR-CM affects the heart

ATTR-CM occurs when a protein called transthyretin (pronounced trans-THY-re-tin) becomes unstable and misfolds.

These pieces join together and form strands of protein called amyloid fibrils that can build up in the body.

Over time, when amyloid fibrils collect in the heart, they cause the heart muscle to thicken, leading to heart failure, which may lead to symptoms such as fatigue, shortness of breath, and peripheral edema.




When amyloid fibrils collect in the heart, they cause the heart to thicken and stiffen over time, eventually leading to heart failure.




In addition to the heart, ATTR-CM can also affect other parts of the body

Amyloid fibrils can also build up in many other parts of the body.

As a result, people can often experience symptoms and conditions that seem unrelated to the heart, such as:

Bilateral carpal tunnel syndrome (numbness, tingling, or pain in your fingers)

Pain or numbness in the lower back or legs due to narrowing of the lower spine (known as lumbar spinal stenosis)

Gastrointestinal issues (eg, diarrhea, constipation, nausea, or feeling full quickly)

Decreased or strange tingling sensation/pain in toes/feet (known as peripheral neuropathy)




These symptoms can be early indicators of ATTR-CM.